Generalized anxiety disorder (GAD) is marked by uncontrollable, persistent worry and exaggerated response to uncertainty. Here, we review and summarize the findings from the GAD literature that employs functional neuroimaging methods. In particular, the present review focuses on task-based blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies. We find that select brain regions often regarded as a part of a corticolimbic circuit (e.g., amygdala, anterior cingulate cortex, prefrontal cortex) are consistently targeted for a priori hypothesis-driven analyses, which, in turn, shows varying degrees of abnormal BOLD responsivity in GAD. Data-driven whole-brain analyses show the insula and the hippocampus, among other regions, to be affected by GAD, depending on the task used in each individual study. Overall, while the heterogeneity of the tasks and sample size limits the generalizability of the findings thus far, some promising convergence can be observed in the form of the altered BOLD responsivity of the corticolimbic circuitry in GAD.

The events we experience day to day can be described in terms of their affective quality: some are rewarding, others are upsetting, and still others are inconsequential. These natural distinctions reflect an underlying representational structure used to classify affective quality. In affective psychology, many experiments model this representational structure with two dimensions, using either the dimensions of valence and arousal, or alternatively, the dimensions of positivity and negativity. Using fMRI, we show that it is optimal to use all four dimensions to examine the data. Our findings include (1) a gradient representation of valence that is anatomically organized along the fusiform gyrus and (2) distinct sub-regions within bilateral amygdala that track arousal versus negativity. Importantly, these results would have remained concealed had either of the commonly used 2-dimensional approaches been adopted a priori, demonstrating the utility of our approach.

The emergence of social neuroscience in the past two decades has offered a useful neurocognitive framework for understanding human social behavior. Of importance, social neuroscience research aimed to provide mechanistic explanations for the established link between wellbeing and social behavioral phenomena–particularly those reflective of social connectedness. Here, we provide an overview of the relevant literature focusing on recent work using functional magnetic resonance imaging (fMRI). In general, fMRI research demonstrated that aspects of social connectedness that are known to either positively (e.g., social acceptance) or negatively (e.g., social isolation) impact wellbeing also modulated the activity of subcortical reward system accordingly. Similar modulatory influence was found for the activity of other brain regions such as the medial prefrontal cortex, which are typically regarded as components of the “social brain” that support a wide range of functions related to social cognition and behavior. Elucidating such individual differences in brain activity may shed light onto the neural underpinnings of the link between social connectedness and wellbeing.