Summary The level of serum haptoglobin was estimated in favism, thalassemia major, acute rheumatic fever, acute glomerulonephritis, nephrotic syndrome and virus hepatitis. In favism, it was totally absent during the haemolytic episode and then started to rise till it reached normal values after 6‐8 days. Ahaptoglobinaemia was persistent in patients with Thalassemia Major before and after treatment with blood transfusion, dexamethasone administration and splenectomy. In acute rheumatic fever, acute glomerulonephritis and nephrotic syndrome, there was elevation of the haptoglobin level. This could therefore be taken as one of the criteria to evaluate activity of the disease process. The level was low in virus hepatitis and returned to normal with cure. There was a good correlation between the chronicity of the case and the diminution in haptoglobin level.

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