Background: Soybean is an important legume as well as oil seed crop grown in a varied range of climate and soils. Phosphorous and sulphur is an important macronutrient required for plants. Their deficiency in soil is a worldwide concern for production of food crops. Therefore, present investigation was done to study influence of phosphorus and sulphur fertilization on productivity, profitability and quality of soybean. Methods: An experiment conducted during kharif 2021 and laid out in factorial randomized block design with three replications having four levels of phosphorous (0, 20, 40 and 60 kg ha-1) and three levels of sulphur (15, 30 and 45 kg ha-1). The data was recorded, analysed and computed statistically. Result: The results indicated that application of 60 kg P2O5 ha-1 and 45 kg S ha-1 gave significantly higher yield, monetary returns and quality of soybean over rest of phosphorous and sulphur levels. However, it was found at par with 40 kg P2O5 ha-1 and 30 kg S ha-1.