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The purpose of this study was to investigate the antidiabetic effect of phytocompounds from Swietenia macrophylla seed using preliminary phytochemical screening, invitro antioxidant activity and molecular docking studies. The powdered seed extract of Swietenia macrophylla was to investigate the phytochemical screening exhibited the presence of alkaloid, phenols, tannins, flavonoids, terpenoids, steroids, carbohydrates, amino acids and proteins as major active constituents. The antioxidant activity of Swietenia macrophylla seed was evaluated by DPPH free radical scavenging assay. Rutin was used as a reference compound. The Swietenia macrophylla seed exhibited 56.0471% of free radical scavenging activity as compared with rutin. The molecular docking studies performed by using molecular docking server online respectively in which the antidiabetic target namely glutamine:fructose-6-phosphate amidotransferase (GFAT) (PDB id: 2ZJ3) have a potential interaction with swietenine, swietenolide, β-sitosterol, and fucosterol. In this study, the protein glutamine:fructose-6-phosphate amidotransferase (GFAT) was used from its structure perspectives. Its primary and secondary structures were evaluated using online tools. Its role in antidiabetic was assessed by molecular docking the compounds present in the seed extract of Swietenia macrophylla assayed by GC-MS analysis. This in-silico study demonstrates the interactions of active components of Swietenia macrophylla against Type I and Type II diabetes.

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Ethno botanical studies in various parts of Tamil Nadu and other regions were carried out earlier by several research scholars in different times.The traditional healers still strongly believe that medicinal plants and their usage have certain therapeutic values. Documentation on the Utilization of plants for medicinal purposes played a significant role. The present study aims in documenting the ethno botanical usage of medicinal plants for curing various human ailments. A total of 24 selected inhabitants were interviewed and100 medicinal plants species that belonged to 91 genera and 54 families are reported that are used by the traditional healers in Musiri Taluk, Tiruchirappalli District, Tamil Nadu.

Medicinal plants played an important role in the healthcare of domestic animal around the world for several thousand years.The traditional medical systems are generally based on the uses of natural and local medicinal plants. Non accessibility of modern health facilities necessitate that thepractice traditional medicines for their common day ailments of various animals.Relationship animals by the human beings have always been associated with a specific relation with the quality of patient's daily life and personal hygiene. For the present study, a total number of 50 plants belonging different family are reported that are used by the local people to treat various animal disease. The study also suggests that need to adopt appropriate measures that are used in documenting the ethnoveterinary medicinal practices in Pachamalai Hills, Tiruchirappalli District, Tamil Nadu.