The utilization of 5-(hydroxymethyl)furfural (HMF) for the large-scale production of essential chemicals has been largely limited by the formation of solid humin as ab yproduct, which prevents the operation of stepwise batchtype and continuous flow-type processes.The reaction of HMF with 1,3-propanediol produces an HMF acetal derivative that exhibits excellent thermal stability.A erobic oxidation of the HMF acetal with aCeO 2 -supported Au catalyst and Na 2 CO 3 in water gives a90-95 %yield of furan 2,5-dicarboxylic acid, an increasingly important commodity chemical for the biorenewables industry,f rom concentrated solutions (10-20 wt %) without humin formation. The six-membered acetal ring suppresses thermal decomposition and self-polymerization of HMF in concentrated solutions.K inetic studies supported by DFT calculations identify two crucial steps in the reaction mechanism, that is,t he partial hydrolysis of the acetal into 5-formyl-2-furan carboxylic acid involving OH À and Lewis acid sites on CeO 2 ,and subsequent oxidative dehydrogenation of the in situ generated hemiacetal involving Au nanoparticles. These results represent as ignificant advance over the current state of the art, overcoming an inherent limitation of the oxidation of HMF to an important monomer for biopolymer production.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.