BackgroundOver the years, the number of patients with an affected hip joint has been increasing. The pathology of the illness is moving towards a younger age and often handicaps the patients. As their age increases, the symptoms become more acute and endoprosthesis is required. With the complex rheumatologic and physiotherapy treatment, a surgery intervention can be postponed in time, and the symptoms significantly reducedObjectivesTo measure the effect of conducting a one-year complex drug treatment combined with a physiorehabilitation program in patients with hip joint osteoarthritis.MethodsBetween 2010 and 2014, 147 patients with coxarthrosis were hospitalized and treated at the Rheumathology Ward at UMHAT “Georgi Stranski” – Pleven. 58 of them were male and 89 female, aged between 42 and 81, with active arthrosis (ESR<25 mm, fibrinogen and CRP at relevant values, AST and RF (-).In addition to the drug therapy with NSAIDs and chondoprotectors, the patients also undergo a complex physical and rehabilitation program consisting of: electrostimulation, therapeutic massages, kinesitherapy and ergotherapy.Functional tests and measurements were made for the purpose of the study: the movement volume in the affected joints, VAS for the pain, locomotion tests, necessity for any walking aids.ResultsAn individual patient file is created for every patient where his results from the tests and measurements are stored in order to track the patient's condition over the course of one year (which consists of treatment in the Rheumathology ward, treatment in the Medical Rehabiltation ward and ambulatory physiorehabilitation courses).The Wilcoxon rank test (a statistical method for analysis and spreading of non-parametric data) was used to measure the daily activities test results. The Wilcoxon curve shifts to the right, which indicates an improvement of the patients' self-sufficiency and of their quality of life. When applying the VAS test for pain and goniometry, the average values at the beginning and at the end of the observed period are measured and compared. The results show a pain decrease by around 30%, and an increase in the joint movement volume. The ANOVA statistical analysis method was applied to the results of the locomotion test.ConclusionsThe collaboration between rheumatologists and physiotherapists for treatment of patients with coxarthrosis widens the range of daily activities that the patients can perform without experiencing pain, slows down the progression of the deterioration process and makes the daily life of patients more complete and self-sufficient.For patients who are still at working age, the duration of their temporary inability to work is decreased, and they can resume working activities sooner, or they can acquire new professional skills with a lower degree of physical stress which suits their condition and physical abilities. The advent of permanent disability for patients and early endoprosthesis are delayed.The complex physiorehabilitational and rheumathological treatment for patients with hip joi...

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BackgroundGout is a type of arthritis caused by the formation of uric acid crystals within or around the joints. It is the most common type of inflammation arthritis for people over 40.For some of the patients, the leading symptoms are pain and stiffness in the joints, while others develop heavy joint deformations and permanent disabilities. Applying a complex rehabilitation approach with rheumatologic aid and a physio-rehabilitation program significantly improves the condition of the patients with gouty arthritis, the strength of their symptoms diminishes, and becoming handicapped is avoided or significantly delayed.ObjectivesThe aim of this study is to measure the effect of conducting a complex drug treatment combined with a physio-rehabilitation program in patients with gouty arthritis in an acute or chronic stage that heavily affects the musculoskeletal system.MethodsBetween 2013 and 2015, 39 patients with gouty arthritis were hospitalized and treated at the Rheumatology Ward at UMHAT “Dr. Georgi Stranski” – Pleven. 26 of them were male and 13 female, aged between 43 and 62 years old, in subacute or chronic stage (SUE <25 mm, fibrinogen and CRP at relevant values, AST and RF (−).In addition to the drug therapy with analgesics, NSAIDs and chondoprotectors, uricoinhibitors and urikoeliminators during the non-paroxysmal period, the patients also undergo a complex physical and rehabilitation program consisting of: electrotherapy (magnetic field, mid-frequency currents and ultrasound therapy with NSAIDs, therapeutic massages, cryotherapy, active methods of kinesitherapy and occupational therapy.Functional tests and measurements – VAS for the pain, a daily activities life test (DAL) and complex functional assessment test (CFA) – were made for the purpose of the study at the beginning and at the end of the observed period.ResultsAn individual file was created for every patient where the results from the tests and measurements are stored in order to track the patient's condition over the course of treatment. The treatment consists of 3 stages: a period in the Rheumatology ward, treatment in the Medical Rehabilitation ward and ambulatory physio-rehabilitation courses.Conducting physiotherapeutic treatment for patients with gouty arthritis in an acute or chronic stage complements the drug treatment and leads to faster relief of the symptoms during an acute stage, decreases the timeframe of the temporary inability to work, prevents any permanent damage to the affected joints and prevents the occurrence of permanent disabilities.ConclusionsFor patients with gouty arthritis in an acute or chronic stage that heavily affects the musculoskeletal system, the complex physio-rehabilitational and rheumathological treatment is effective and leads to a significant improvement in the quality of life of the patients.Disclosure of InterestNone declared

Development of a standard dosimetric facility with protection against external radiation background for the metrological support of highly sensitive radiation monitoring devices in accordance with the requirements of international standards .

The pro-apoptotic effect of new 2-thioxo-4-thiazolidinone derivative Les-3331 on MCF-7 and MDA-MB-231 cell lines ..