A simple and efficient approach for the synthesis of 2-spirocyclopropyl-indolin-3-ones is herein described. The method involves a diasteroselective cyclopropanation of aza-aurones with tosylhydrazones, selected as versatile carbene sources, and represents...

Satellite associations and silver staining were analyzed in a normal woman carrying three "s" variants, on chromosomes 13, 21, and 22. Six of the acrocentric chromosomes were identified and a positive correlation between the parameters of satellite association frequency and positive silver staining was found for each chromosome. These parameters seem to depend on the presence and size of a secondary constriction and are unaffected by stallelite size.