The paper studies the effect of gamma radiation on the activity of cholinesterase enzyme. The results showed that a change in the activity has occurred in the studied absorbed dose range from 10 KGy to 100 KGy. Proposals to interpret the variation of activity of irradiated cholinesterase enzyme in the studied doses are given. Moreover the effect of time after the radiolysis process on the activity of the enzyme is shown. The final conclusion suggests the replacement of gamma irradiation radiotherapy by alpha or beta radiation for local treatment of tumors to reduce the radiation noxious effects on intact cells and enzymes
The publication demonstrates chelation studies of cobalt(III) with 1,2 bis(betaaminoethoxy)ethane N,N,N',N' sodium sulfonate triacetic acid (ASTA). The results showed the effectiveness of ASTA as a chelating agent by molar ratio , continuous variation and slope ratio methods. Stable complex 1:1 was formed at pH from 6.0 to 10.5. Solutions of Co-ASTA chelate of different molar ratios at pH 6.5 and 8.0 were irraiated by different gamma radiation doses. The results showed a linear decrease of absorbance with dose which can be utilized as a dosimeter for weak dose rate measurement in the studied range. A proposed radiolytic mechanism is discussed. The degradation of ligand has been related to hydroxyl radical attack.
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