In man the Sd^a antigen is present in most secretions
with the greatest concentration in urine. There is little
difference in the amount of Sd^a substance in the urine of newborn
infants, pregnant women and normal adults but there is
a much greater amount in the saliva of newborn infants than
in adults. Approximately half the people whose red cells group
as Sd(a-) secrete Sd^a substance in the urine. Anti-Sd^a antibody
is present in 50% of Sd(a-) non-secretors of Sda substance, though most of these
antibodies only react with the strongest Sd(a+) cells. The greatest Sda activity
has been found in human meconium, guinea pig urine and guinea pig kidney.
Activity can be detected in the urine of many animal species. The kidneys of 5 bird
species did not contain Sd^a.
Antigenic sites of Bg^b and Bg^c specificity are present on lymphocytes
as well as on red cells. The Bg^b group has been correlated with the W17 (Te57)
white cell group, and the Bg^c with the W28 (Da15,Ba*) antigen. Both haemagglutinating
and cytotoxic antibodies can be absorbed by either red or white cells,
though cross-reactivity was shown by many white cells. A haemagglutinin reacting
with HL-A10 positive donors was found in some multispecific antisera. All these
groups show weaker reactions with red cells than with lymphocytes.
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