Background The role of radioiodine treatment following total thyroidectomy for differentiated thyroid cancer is changing. The last major revision of the American Thyroid Association (ATA) Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer in 2015 changed treatment recommendations dramatically in comparison with the European Association of Nuclear Medicine (EANM) 2008 guidelines. We hypothesised that there is marked variability between the different treatment regimens used today. Methods We analysed decision-making in all Swiss hospitals offering radioiodine treatment to map current practice within the community and identify consensus and discrepancies. Results and ConclusionWe demonstrated that for low-risk DTC patients after thyroidectomy, some institutions offered only follow-up, while RIT with significant activities is recommended in others. For intermediate-and high-risk patients, radioiodine treatment is generally recommended. Dosing and treatment preparation (recombinant human thyroid stimulation hormone (rhTSH) vs. thyroid hormone withdrawal (THW)) vary significantly among centres.

Purpose: Cancer is a leading cause of global childhood mortality from noncommunicable diseases. While many cancer types are curable with current treatment regimens, the 90% of children and adolescents diagnosed with cancer in low- and middle-income countries (LMICs) have limited access to these treatments and markedly lower survival rates. Hospital based cancer registries (HBCRs) are essential to understanding improvements in treatment through the collection of patient information that allows for assessment of the impact of quality improvement. The St. Jude Global Childhood Cancer Analytics Resource and Epidemiological Surveillance System (SJCARES) is a standardized, cloud-based tool kit that was designed to assist LMICs with data collection on childhood cancer diagnoses and outcomes. Based on our observations of wide variation in the speed and success of HBCR implementation at participating LMIC sites during the first year, our aim is to investigate the barriers and facilitators to successful HBCR implementation. Methods: Eight of 89 participating SJCARES registry sites were randomly selected within region and implementation stage representation. Webinars were conducted to inform and recruit HBCR study participant teams. An adapted interview guide for LMICs was created utilizing the Consolidation Framework for Implementation Research. Forty-five minute semi-structured Zoom interviews with study participant teams from these 8 sites were conducted to evaluate barriers and facilitators for HBCR implementation. Transcripts will be thematically coded using rapid qualitative analysis. Results: Of the 8 participating sites, 1 is in the administrative, 2 are in the piloting, and 5 are in the production phases. Sixteen members from study participant teams (9 clinicians, 4 administrators, and 3 data clerks) from these sites were interviewed to identify barriers and facilitators associated with successful HBCR implementation. Rapid qualitative analysis of the interview transcripts to identify themes will be completed by February 2023. Conclusions: This study will elucidate modifiable barriers and facilitators impacting the SJCARES Registry implementation in LMICs. Findings will help identify strategies to support successful and sustainable HBCRs in LMICs. Thus, this study will support equity among LMICs to promote widespread adoption of sustainable HBCRs and grow the infrastructure required to improve and sustain access to quality therapies and supportive care. Citation Format: James Collins, Michele Muir, Allison Yang, Melissa Maas, Courtney Canter, Nickhill Bhakta, Kim Johnson, Benyam Muluneh. Barriers and Facilitators to Implementation of Hospital-Based Pediatric Cancer Registries in Resource-Limited Settings [abstract]. In: Proceedings of the 11th Annual Symposium on Global Cancer Research; Closing the Research-to-Implementation Gap; 2023 Apr 4-6. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(6_Suppl):Abstract nr 11.

People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

No abstract