Background(VPT) children and adolescents exhibit executive, behavioural and socio-emotional difficulties that persists into adulthood. Previous research suggests that mindfulness-based intervention (MBI) may specifically target the development of theses competences. The objective of the current study is to describe the study protocol and to evaluate the feasibility of a clinical trial on a MBI program to enhance executive, behavioural and socio-emotional competences in a cohort of VPT young adolescents.Methods164 VPT young adolescents from 10 to 14 years old, born before 32 gestational weeks, were invited to participate in an MBI program of 8 weekly sessions in groups of up to 8 participants, lasting 1h30. Participant were enrolled in a randomised controlled trial (RCT) or in a pre-post intervention designs depending of their availability. Satisfaction and attendance measures of the MBI were collected using self-reported questionnaires and registration of attendance.ResultsOf the 63 participants who were enrolled in the study (38.2% of families invited to participate), 52 (82.5%) completed all assessments. Once enrolled, acceptability was high as shown by the high attendance rate in the sessions and the feedback evaluation questionnaire.DiscussionTo our knowledge, this is the first study to investigate the feasibility of an MBI study in VPT born young adolescents. Our findings suggest that an MBI study is feasible and show a high acceptability among participants. The use of an RCT design in our study constitutes the gold standard for testing the efficacy of such intervention in VPT young adolescents. If effective, the MBI program could potentially be a valuable tool for improving executive, behaviour and socio-emotional competences in the vulnerable VPT population.Trial registrationClinicalTrials, NCT04638101. Registered 19 November 2020 - Retrospectively registered, https://clinicaltrials.gov/show/NCT04638101.