Ryle's tube insertion is a simple routine clinical procedure usually without any complications. Minor complications like injury to nasal or oral cavity and epistaxis may occur with the insertion of Ryle's tube. However it can lead to occasional unexpected life threatening complications such as esophageal or pulmonary perforation, pneumothorax, intravascular penetration or entry into the cranial cavity. Herein, we report a case of supra-glottic edema due to Ryle's tube insertion leading to stridor necessitating tracheostomy. We recommend that the Ryle's tube should be inserted by adequately trained personnel and its correct position should always be confirmed.