Matrix metalloproteinases (MMPs) are involved in many physiological and pathophysiological processes, including tumor cell invasion and metastasis. For one member of this family, MMP-13 (collagenase-3), a new, highly specific ELISA with a sensitivity of 0.5 ng MMP-13/ml was established. The protein levels of MMP-13 in ascitic fluids of 30 patients with advanced ovarian cancer FIGO stage III (n = 19) and IV (n = 11) were measured with this ELISA. Using a cut-off value of 0.5 ng MMP-13/mg total protein, two patient subpopulations with short (median 16 months) and long (median 36 months) overall survival were identified. Together with other prognostic markers, determination of MMP-13 in ascitic fluid may help to identify patients at risk for early death and help to individualize adjuvant therapy.

In the present study the relationship between profile characteristics of rural youth and the perception towards agriculture were discussed. The results revealed that scientific orientation was positively significant with the perception. Marital status, Land holding, Family type, Extension contact, Social participation, Mass media exposure, Economic motivation, Risk orientation Achievement motivation of rural youth were positively significant with the perception. On the other side, the variables like Annual income, Size of family, Occupation were found to be positively non-significant related with the perception of rural youth, whereas education was found to be negatively non-significant with the perception. The multiple linear regression analysis shows that marital status, land holding, size of family, family type, social participation, mass media exposure, economic motivation and risk orientation significantly contributed their perception towards agriculture as an occupation.

Aim: To find out the direct and residual effect of application of organics, inorganics and their combination on yield and yield parameters of rice-maize cropping system. Study Design: The experiment was laid out in randomized block design during kharif season and split plot design during rabi. Place and duration of Study: At Agricultural college farm, Bapatla during 2018-19 and 2019-20. Methodology: After the preliminary layout, paddy was sown in kharif and maize was sown in rabi season. Vermicompost and green leaf manure were applied two weeks before sowing of paddy. Treatments applied for paddy were considered as main plots and each main plot was divided into two sub plots during rabi. Results: Higher grain yield, straw yield, drymatter production at tillering stage were recorded with the application of 50% RDN through vermicompost +50% RDN through inorganics (T9) during both the years of study. However, in succeeding maize, the kernel yield, straw yield and yield attributing characters (drymatter, cob length and test weight) were significantly highest in the treatment which received 75% RDN through green leaf manure+ 25% RDN through inorganic (T5). Among the fertilizer levels applied to maize, S2 (100% RDF) recorded significantly higher dry matter production over S1 (50% RDF) at all the stages of crop growth and during two years of experimentation. Conclusion: Substitution of 50 % N through vermicompost improved rice yield and yield attributes whereas substitution of 75% N through GLM have shown better residual effect in terms of improvement of yield and yield attributing characters of maize. Among the subplots application of 100% RDF significantly increased the yield when compared to 50% RDF.

An investigation was carried out in no-till sorghum to assess the direct and residual effect of phosphorus management of sorghum in rice-sorghum sequence during rabi, 2016-17 and 2017-18 on clay loam soils of Agricultural College Farm, Bapatla. All treatments are randomly allocated in three replications in a split plot design for kharif season and splitsplit plot design for rabi season in both the years of study. The most popular sorghum hybrid CSH-16 was used for experimental purpose. Results showed that a significant increase in plant height, drymatter accumulation, yield attributes and grain yield of sorghum were observed with green manuring insitu with dhaincha + PSB applied to rice on succeeding no-till sorghum and 50 % RDP given to sorghum. There was no significant difference was observed on growth and yield parameters of sorghum where 50 % RDP given to rice on sorghum.

Aims: To evaluate the effect of manures in combination with biofertilizers consortium on  yield and rhizosphere biota in rice fallow sorghum Study Design: The experiment was laid in a Randomized Block Design (RBD) with seven treatments and replicated thrice. Place and Duration of Study: At Agricultural college farm, Agricultural college, Bapatla during Rabi, 2018-19. Methodology: After the preliminary layout, Bio-fertilizer consortium contains 500ml each of Azospirillum, PSB and KRB in liquid form had been applied per acre along with Vermicompost @ 1 t ha-1 is used as carrier. A high yielding hybrid CSH-16 with a yield potential of 5 to 8 t ha-1 and matures in 110-120 days. Sowing was done manually by using a seed rate of 12 kg ha­­-1 and adopting a spacing of 45 cm x 15 cm raised well in advance in their respective treatments. Results: Yield attributes, Grain yield and stover yields were obtained maximum with 125% RDF+ Biofertilizers consortium which was on par with 100% RDF+ Biofertilizers consortium. In case of Bacterial, fungal and actinomycetes population were also influenced significantly at harvest compared to initial population of the observed soil and recorded the highest population with 125% RDF+ Biofertilizers consortium treatment. Conclusion: The fertilizer requirement with application of 125% RDF+ Biofertilizer can be recommended for coastal region of A.P under rice fallow rabi sorghum in no till conditions. As it resulted in high yield attributes, yields and significant improvement in rhizosphere biota for soil health enhancement.