A retrospective study of 60 renal biopsies obtained from nephrotic subjects with schistosomiasis showed amyloid deposits in 10 cases. Distribution was usually segmental, mainly mesangial and overlapped with the conventional mesangio-proliferative lesions of schistosomiasis. The invariable clinical presentation was proteinuria with generalized oedema of insidious onset and a slowly progressive or intermittent course. Differences from conventional schistosomal nephropathy are described. Response to anti-schistosomal treatment was very poor. Repeat renal biopsies showed no regression of the lesions. The possible links between schistosomiasis and amyloidosis are discussed and causes of amyloid deposition suggested.

Fifteen cases of juvenile nasopharyngeal fibromata have been studied clinically and histologically, and their structure has been compared to that of genital erectile tissue obtained from autopsies of foetuses and children. A similarity in the structure of these two tissue could be observed. A concept of juvenile nasopharyngeal fibroma as arising from misplaced sequestrated genital erectile tissue during foetal development, is discussed; and support is given to this view by anatomical, clinical and histological data.

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Cigarette smoke has an injurious effect on vocal fold polyp epithelium and leads to increased hyaline degeneration in polyps.