Phenolic acids are a large class of compounds occur naturally in a variety of plants and exhibit a wide range of biological activities, but toxic effects have also been observed. This study was designed to assess genotoxic effect of two selected phenolic acids, gallic and ellagic, in somatic and germ cells of Drosophila melanogaster using the sex-linked recessive lethal (SLRL) test and comet assay in vivo. The obtained results revealed that tested phenolic acids did not induce genotoxic effect and therefore have a safety margin for therapeutic use.