The photoreactivity of the nonsteroidal anti-inflammatory 2-arylpropionic acids benoxaprofen, carprofen, naproxen, ketoprofen, tiaprofenic acid, and suprofen is reviewed with special emphasis on fundamental photophysical and photochemical properties. The absorption and emission properties of the excited states of these drugs as well as their main photodegradation routes are summarized. The photochemical mechanisms are discussed on the basis of product studies and detection of short-lived intermediates by means of laser flash photolysis. After dealing with the unimolecular processes, attention is focused on the photosensitized reactions of key biomolecules, such as lipids, proteins or nucleic acids. Finally, a short section on the photobiological effects on simple biological models is also included. Although some earlier citations are included, the literature coverage is in general limited to the last decade.
In multimedia and other streaming applications a significant portion of energy is spent on data transfers. Exploiting data reuse opportunities in the application, we can reduce this energy by making copies of frequently used data in a small local memory and replacing speed and power inefficient transfers from main off-chip memory by more efficient local data transfers. In this paper we present an automated approach for analyzing these opportunities in a program that allows modification of the program to use custom scratch pad memory configurations comprising a hierarchical set of buffers for local storage of frequently reused data. Using our approach we are able to reduce energy consumption of the memory subsystem when using a scratch pad memory by a factor of two on average compared to a cache of the same size.
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