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The aim of this study was to assess how the administration of prostaglandin E₁ incorporated in lipid microspheres (Lipo PGE₁) affects liver injury and regeneration after massive hepatectomy in rats. Two hundred and eight male Wistar rats underwent 90% partial hepatectomy. Lipo PGE₁ of 1, 10 or 30 μg/kg were administered intraperitoneally at 6 h prior to and 0 and 6 h after hepatectomy. Postoperative increases in serum GOT, total bilirubin, IL-6 and plasma endotoxin levels were significantly suppressed by Lipo PGE₁. The depressed phagocytic index and arterial ketone body ratio and hepatic DNA synthesis after 90% partial hepatectomy were significantly enhanced by Lipo PGE₁, which resulted in the improvement of survival. Lipo PGE₁ might bring about a protective effect on liver injury and an enhancement of liver regeneration after massive hepatectomy.

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