Being a confirmed TB patient was directly proportional to e-nose 10-sensor responses. Principal component analysis clusters showed a clear distinction between TB and HC groups, with variances of 93%, 85%, 75% and 95% for blood, breath, sputum and urine samples, respectively. Overall accuracy, sensitivity and specificity of the artificial neural network (ANN) analysis for classifying samples were >99%. The e-nose successfully distinguished TB patients from HC participants for all measured biological samples with great precision. With urine samples gaining broader acceptance for clinical diagnosis, an e-nose-based ANN can be a very useful tool for low-cost mass screening and early detection of TB patients in developing countries.

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Background Distinguishing asthma from COPD can be difficult especially among old age and smokers. Some patients have common features of asthma and COPD.1 (GINA, 2018). Hence, the definition of asthma COPD overlap (ACO) was developed. ACO is a considerable risk factor for healthcare utilization versus the general population, the asthma population and the COPD population.2(Minchul Kim et al., 2019). Fungal sensitization increase severity of asthma. Aim of the study To compare the prevalence of aspergillus fumigatus sensitization among ACO patients versus asthmatic patients and healthy normal control. Patients and Methods 90 individuals were included; 30 diagnosed as bronchial asthma (According to GINA 2018), 30 ACO patients and 30 healthy normal control. All are group matched to age and sex and selected from the allergy and chest outpatient clinics at Ain shams University hospitals. Total IgE, skin test for Aspergillus and spirometry were done to all participants. Results Aspergillus sensitization was more prevalent among ACO group compared to asthma group however, all control individuals were negative to aspergillus. FEV1 was significantly lower among ACO and asthma groups when compared to control. FEV1 increased significantly in the three groups after albuterol inhalation. Conclusion sensitization to Aspergillus was more among ACO patients compared to Asthma and control groups.