Blood cockle (Anadara granosa) can accumulate heavy metals in the waters. The purpose of this study was to analyze the heavy metal content of lead, cadmium, and arsenic in blood cockle in Jepara waters through fish landing area Kedung and to determine the effectiveness of liquid smoke as a source of acetic acid in reducing heavy metal in blood cockle. The addition of liquid smoke concentrations of 0%, 4%, 5%, and 6% in distilled water, then the blood cockle soaked for 60 minutes and repeated 3 times. Control and blood cockle soaked in liquid smoke were tested for heavy metals (ICP-MS), protein, water, pH, and organoleptic levels. Heavy metal levels of lead, cadmium and arsenic in blood cockle in Jepara were 0.41±0.08(mg/kg), 1.25±0.07(mg/kg), and 1.28±0.17(mg/kg). The results showed a significant difference P<5% in the reduction of heavy metals with liquid smoke. The lowest decreasing value at concentration of 4% of 25 until 27%, while the highest decrease was at a concentration of 6% 57 until 78%. Soaking blood cockle with liquid smoke as source of acetic acid effectively reduces heavy metal levels and maintains the quality of blood cockle.