The article presents data on the relevance of use of adhesive materials when using removable laminar prostheses under various conditions prosthetic bed in patients with complete absence of teeth; on the development of optimal formulations and methods of making adhesive compositions for removable laminar dentures, modified with silver ions, with pronounced antimicrobial activity, bioinertness and high fixing properties to improve fixation and stabilization of removable partial dentures complete dentition in the period of adaptation of patients to newly manufactured prostheses and in the process further their use; and described in detail a number of studies on the physico-mechanical characteristics of the developed material on the basis of technical laboratories: Federal state budgetary educational institution of higher professional education «Voronezh state medical University named after N. N. Burdenko» Ministry of health of the Russian Federation, company for the production of dental materials «Celite» (Voronezh); and in clinical practice: on the basis of the dental clinic of the «VSMU them. N. N. Burdenko» Ministry of health of Russia and in private dental clinics, under which was revealed quite pronounced fixing properties of the modified compositions in relation to the base removable laminar denture and tissues of the prosthetic bed, when proven to this antibacterial activity and bioinertness developed material, thereby clearly defines the relevance of the use of the adhesive composition, modified with silver ions, as an effective means to improve the fixation and stabilization of removable partial dentures in the oral cavity of patients with complete absence of teeth, contributing to more comfortable with their further operation.