Background: Cancer subtype identification is an active research field which helps in the diagnosis of various cancers with proper treatments. Leukemia is one such cancer with various subtypes. High throughput technologies such as Deoxyribo Nucleic Acid (DNA) microarray are highly active in the field of cancer detection and classification alternatively. Objective: Yet, a precise analysis is important in microarray data applications as microarray experiments provide huge amount of data. Gene selection techniques promote microarray usage in the field of medicine. The objective of gene selection is to select a small subset of genes, which are the most informative in classification. associations while known disease-lncRNA associations are required only. Method: In this study, multi-objective evolutionary algorithm is used for gene subset selection in Leukemia classification. An initial redundant and irrelevant gene removal is followed by multiobjective evolutionary based gene subset selection. Gene subset selection highly influences the perfect classification. Thus, selecting the appropriate algorithm for subset selection is important. Results: The performance of the proposed method is compared against the standard genetic algorithm and evolutionary algorithm. Three Leukemia microarray datasets were used to evaluate the performance of the proposed method. Perfect classification was achieved for all the datasets only with few significant genes using the proposed approach. Conclusion: Thus, it is obvious that the proposed study perfectly classifies Leukemia with only few significant genes.</P>

The fact that reflects the cancer research consequences shows that still there are improvements that should be investigated in the stream of cancer in future. This leads the researchers to actively involve further in cancer research field. As an invention, a hybrid machine learning method is proposed in this study where two filters are assessed along with a wrapper approach. Typically, filters prioritize the features while, wrappers contribute in subset identification. Though both filters and wrappers exist independently, the excellent results they produce when applied subsequently. The wrapperfilter combination plays a major role in feature selection. Yet, incorporating with a best strategy for feature space analysis is crucial in this concern. Thus, we introduce the Evolutionary Algorithm in the proposed study to search through the feature space for informative gene subset selection. Though there are several gene selection approaches for cancer classification, many of them suffer from law classification accuracy and huge gene subset for prediction. Hence, we propose Evolutionary Algorithm to overcome this problem. The proposed approach is evaluated on five microarray datasets, where three out of them provide 100% accuracy. Regardless the number of genes selected, both filters provide the same performance throughout the datasets used. As a consequence, the Evolutionary Algorithm in feature space search is highlighted for its performance in gene subset selection.