Copolymers based on aliphatic diamines of various methylene chain lengths and guanidine hydrochloride were prepared by polycondensation in the melt. Antibacterial activity of water-soluble copolymers based on guanidine against conditionally pathogenic microorganisms Escherichia coli and Bacillus cereus was evaluated using diffusion in agar. A relationship was found between the ratio of the number of hydrophobic methylene groups to the number of ionized guanidines and the antibacterial activity of the copolymers. Several samples showed high antimicrobial activity as compared with polyhexamethyleneguanidine hydrochloride (PHMGHC), which is widely used as a medical disinfectant.

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Conclusion. Thus, on the model of a linear cutaneous wound, a muscular wound, and a thermal burn, the healing effect of the hydrogel PGMGh/f is established, as evidenced by the results of the early exercise, vulnografiya and pathomorphological studies. It is noted that the hydrogel PGMG h/f has an effect on the content of antioxidants and leukocytes in the blood, contributing to the normalization of their quantity.

The study aims to obtain polyhexamethylene guanidine hydrochloride hydrogel compositions with extracts of medicinal plants growing in the Baikal region (Bergenia crassifolia, Calendula officinalis, Tussilago farfara) to evaluate sorption activity and consider the subsequent use of the compositions as an external wound healing agent. It has been shown that hydrogel sorbs mainly caffeinequinic acids in various compositions. It has been made an assumption about a link of sorption process with formation of secondary amino groups’ complex in the hexahydrotriazine cycle, which is formed as a result of gelation of PHMGhch, and carboxyl groups of extract substances. It is planned to study the wound healing activity of compositions by modeling skin damage of laboratory animals in future researches.