The preventive effects of contrast media containing ulinastatin (UST) and/or prednisolone (PDN) on potential complications associated with endoscopic retrograde cholangiopancreatography (ERCP) were studied in 111 patients. The incidence of abdominal pain and the elevation in the serum amylase level after ERCP were lower in the UST group than in the control group and abdominal pain and the elevated serum amylase level were almost completely suppressed in the PDN and UST/PDN groups. Based on these findings, a comparative study was conducted to evaluate the effectiveness of a combination of UST and PDN, given via the pancreatic duct, in alleviating pain symptoms in 57 patients with chronic pancreatitis and abdominal pain. The post-ERCP serum amylase level in some patients in the PDN and UST/PDN groups was lower than the pretreatment value. After ERCP, the abdominal pain that had been experienced before ERCP was relieved, and the value of the bentiromide-paraaminobenzoic acid (BT-PABA) test had improved. These results suggest that the use of contrast media containing PDN or UST/PDN in patients with chronic pancreatitis is extremely effective not only for preventing potential complications related to ERCP but also as a new diagnostic treatment method.

We have evaluated the radioimmunoassay for type I procollagen carboxy terminal peptide (type I C-peptide), which is liberated from type I procollagen during its conversion to coliagen, in the serodiagnosis of scirrhous carcinoma of the stomach. The mean (SD) serum concentration of type I C-peptide in 39 normal subjects was 41.7 (19.7) ng/ml. The mean serum values and the positive ratio oftype I C-peptide in 11 patients with stages II and IH scirrhous carcinoma of the stomach were 91.2 (41.9) ng/ml and 54.5%, respectively. In 10 patients with other types of gastric carcinoma, the mean type I C-peptide values were not significantly different from the normal value. Serum type I C-peptide values reflected the clinical course of scirrhous gastric carcinoma in five patients who underwent either operation or chemotherapy. The measurement of serum type I C-peptide concentrations could provide a useful way of diagnosing and monitoring scirrhous carcinoma of the stomach.

Chlorella T‐1 is a micro algae which carries out highly active photosynthetic carbon fixation. For searching the ·OH scavenging molecules in this strain, the methanol extract of T‐1 was fractionated by RP‐HPLC and the fractions were analyzed for DMPO‐OH formation by ESR after Fenton reaction. In the course of study, a single chlorella T‐1 ingredient was found to enhance the formation of DMPO‐OH rather than scavenge in the Fenton system. The ·OH enhancing chlorella component was further purified by chromatography and finally identified as lactic acid by NMR and LC‐MS. From the analysis of the reaction conditions for DMPO‐OH, it was found that lactic acid did not serve as direct source of ·OH but accelerated Fenton reaction.

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Various reports have been published on the causative factors of polyp of the vocal cords .In the present study, laryngeal polyps were examined by optical and electron microscopy, with special respect on the allergic reactions which are regarded a one of its possible causative factors. For electron microscopic examination, materials were stained with PAM. or Ruthenium Red, which are usually employed to demonstrate mucopolysaccharides.This study was conducted on the 124 patients with laryngeeal polyp who visited our clinic during the five year period from April, 1970 to March, 1975. All of their polyps were removed by laryngo-micro surgeny NLA.The results were as follows. 1) Clinical ExaminationThe polyps were most frequently found in the anterior and middle one-third of the vocal cords (about 50 %). It can be said that this is due to the distribution of blood vessels, specificity of vascular structure, and the torsional movement of the vocal cords muscules. 2) Electron Microscopic ObservationsElectron microscopic examination revealed the degeneration and dilatation of intercellular space of mucosal epithelium and intracellular edema. In the mucosal matrix, dilatation of microvasculature, hemangioma-like degeneration, and perivascular infiltrations of histiocytes or other mononuclear cells were noted. Moreover, marked microfiber and fibrostic substances were observed. In many cases, an increase in the acidic mucopolysaccharides and PAM-stain positive colloidal fiber in the matrix were noted, as well as an increase of the capillary permeability.Although various reports have been published, on the causative factors of the polyp of the vocal cords, it can be said that the disease may be caused by various factors rather than by a single factor.In this study, detailed electron microscopic observation was made on the shaft like structure which is specific for the peripheral blood vessels in the vocal cords and found that immunological factors are important in the pathogenesis of this disease. The local abnormalities and the specificity of blood vessels of the vocal cords are also important factors.