Siddha herbo mineral formulation Ayakaandha Abraga Chendhuram indicated as a best choice of drug to treat diabetes. AAC was evaluated for its antidiabetic activity on streptozotocin induced diabetes in rats. At the end of the results, can found that these drug AAC has hypoglycaemic effect. Oral administration of AAC (25mg/kg), significantly reduced the elevated blood glucose levels as the duration of drug administration increases. Further clinical study will be carried out for the benefit of diabetes patients.