Background. Pseudohypoparathyroidism (PHP) refers to broad spectrum of genetic diseases characterized by the peripheral resistance to parathormone (PTH). This condition leads to hypocalcaemia, hyperphosphatemia and elevated PTH concentrations. There is scant literature on PHP in pregnancy, only nine cases published. The treatment of the disease in pregnant women is challenging. The main target is to avoid hyper/hypocalcaemia in order to prevent maternal adverse effects and to protect the development of the foetal parathyroid glands. Case presentation. We report a rare case of PHP type 1b in a pregnant woman, managed by a multidisciplinary team and treated with a tailored therapy. Conclusions. Good compliance with therapy, regular biochemical and clinical monitoring, and a multidisciplinary management are probably the best way to manage this condition in pregnancy.
Radiologic imaging in the evaluation of pregnant patients has significantly grown with the outbreak of the severe acute respiratory syndrome related to SARS-CoV-2 pandemic. Lung ultrasound is an emerging non-invasive bedside technique used to diagnose interstitial lung syndrome through evaluation and quantitation of the number of B-lines, pleural irregularities and nodules or consolidations. In pregnant COVID-19 patients, lung ultrasound should be considered on account of its various strengths, such as its being easily carried out bedside by trained sonographers for the monitoring of lung involvement in follow-ups, and its repeatability and affordability. However, pregnant patients could need chest radiography or computed tomographic (CT) examinations for the diagnosis of pneumonia. Concerns and misconceptions about potential radiation-related risks for the embryo or fetus are still widespread among clinicians and can lead to excessive anxiety among patients. Several well-recognized guidance documents were published in the last years as to the safety of a single-phase CT or an X-ray chest and related carcinogenic and teratogenic risk. This paper summarizes the safety of radiological examination for pneumonia in pregnant women affected by COVID 19, based on the estimated embryo-fetal radiation absorption per procedure (mGy).
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