BackgroundIn Argentina we have witnessed two COVID 19 waves between 2020 and 2021. The first wave occurred during the spring of 2020 and it was related to the wild type of the virus, the second occurred during the fall/winter of 2021 when the gamma variant showed a clear predominance. During the first wave, patient with rheumatic diseases showed a higher frequency of hospitalization and mortality (4% vs 0.26%) when compared to the general population1; at that time, however, vaccination was not yet available.ObjectivesTo compare sociodemographic and disease characteristics, course and outcomes of SARS-CoV-2 infection in patients with immune-mediated/autoinflammatory diseases (IMADs) during the first and second waves in Argentina.MethodsSAR-COVID is a national, multicenter, longitudinal and observational registry, in which patients ≥18 years of age, with a diagnosis of a rheumatic disease who had confirmed SARS-CoV-2 infection (RT-PCR or positive serology) were consecutively included since August 2020. For the purpose of this report, only patients with IMADs who had SARS-CoV-2 infection during the first wave (defined as cases occurred between March 2020 and March 2021) and the second wave (cases occurred between April and August 2021) were examined. Sociodemographic characteristics, disease diagnosis and activity, comorbidities, immunosuppressive treatment and COVID 19 clinical characteristics, complications and outcomes: hospitalization, intensive care unit (ICU) admission, use of mechanical ventilation and death were compared among groups. Descriptive statistical analysis was performed. Variables were compared with Chi squared test and Student T test or Mann Whitney test. Multivariable logistic regression models with forward and backward selection method, using hospitalization, ICU admission and death as dependent variables were carried out.ResultsA total of 1777 patients were included, 1342 from the first wave and 435 of the second one. Patients had a mean (SD) age of 50.7 (14.2) years and 81% were female. Both groups of patients were similar in terms of socio-demographic features, disease diagnosis, disease activity, the use of glucocorticoids ≥ 10 mg/day and the immunosuppressive drugs (Table 1 below). Patients infected during the first wave have higher frequency of comorbidities (49% vs 41%; p= 0.004). Hospitalizations due to COVID 19 (31% vs 20%; p <0.001) and ICU admissions (9% vs 5%; p= 0.009) were higher during the first wave. No differences in the use of mechanical ventilation (16% vs 16%; p= 0.97) nor in the mortality rate (5% vs 4%; p= 0.41) were observed. In the multivariable analysis, after adjusting for demographics, clinical features and immunosuppressive treatment, patients infected during the second wave were 40% less likely to be hospitalized (OR= 0.6, IC95% 0.4-0.8) and to be admitted to the ICU (OR= 0.6, IC95% 0.3-0.9).Table 1.Variable (% or Mean – SD)First wave(n=1342)Second wave(n=435)p ValueFemale gender81800.7Age (years)51.0 (14.5)50.0 (13.3)0.2Disease diagnosis Rheumatoid arthritis46461 Ankylosing spondylitis10110.8 Systemic lupus erythematosus171850.9 Systemic Scleroderma551 Sjögren´s syndrome650.7 Inflammatory myopathies330.5 Vasculitis430.4Disease activity High430.5Use of immune modulatorsDMARDcs53560.2DMARDts460.1DMARDb82821Use of glucocorticoids ≥10 mg12120.9Comorbidities49410.004ConclusionThe impact of COVID 19 in Argentina, in terms of mortality in patients with IMADs was still higher compared to the general population during the second wave. However, the frequency of hospitalizations and ICU admissions was lower. These findings could be explained by the introduction of the SARS COV 2 vaccination and, probably, by the cumulative knowledge and management improvement of this infection among physicians.References[1]Isnardi CA et al. Epidemiology and outcomes of patients with rheumatic diseases and SARS-COV-2 infection: data from the argentinean SAR-COVID Registry. Ann Rheum Dis, 2021, suppl 1, 887.Disclosure of InterestsNone declared

BackgroundMany activity indices have been developed for Systemic Lupus Erythematosus. However, they present important limitations due to the multi-organ compromise.The SLEDAI score and its different versions are widely used in daily practice and in clinical research.Diogo Jesus et al (2018) developed the SLE-DAS (Systemic Lupus Erythematosus Disease Activity Score), that include 17 items, 4 of them continuous. SLE-DAS assesses disease activity in the 28 previous days using an online calculator, with clinical characteristics non-evaluated by SLEDAI. It showed greater precision to measure disease activity, greater sensitivity to detect clinically significant changes and better performance to predict accumulated damage than SLEDAI. It has not yet been validated in Argentina.ObjectivesTo determine the validity of the SLE-DAS score in a population of patients with SLE from Argentina.MethodsA multicenter observational study was conducted. Outpatients and hospitalized patients with SLE from 9 Argentinian centers were included between July to August 2021. Socio-demographic and disease variables were studied and SLE activity was measured by physician’s global assessment (PGA), SLEDAI 2K and SLE-DAS. The disease activity categories used for SLE-DAS were: remission ≤2.08; mild activity >2.08 to 7.10, moderate and severe activity >7.10. For SLEDAI 2K, remission was considered 0, mild activity 1 to 5, moderate 6 to 10, high 11 to 19, very high >20 points.To determine construct validity and criterion validity, SLEDAI 2K and PGA were used as the gold standard and correlation between scores was analyzed with the Pearson and Spearman correlation coefficient. Sensitivity and specificity of the points that define each of the activity levels were established by ROC curves to determine the discriminative capacity of SLE-DAS.ResultsA multicenter observational study was conducted. Outpatients and hospitalized patients with SLE from 9 Argentinian centers were included between July to August 2021. Socio-demographic and disease variables were studied and SLE activity was measured by physician’s global assessment (PGA), SLEDAI 2K and SLE-DAS. The disease activity categories used for SLE-DAS were: remission ≤2.08; mild activity >2.08 to 7.10, moderate and severe activity >7.10. For SLEDAI 2K, remission was considered 0, mild activity 1 to 5, moderate 6 to 10, high 11 to 19, very high >20 points.To determine construct validity and criterion validity, SLEDAI 2K and PGA were used as the gold standard and correlation between scores was analyzed with the Pearson and Spearman correlation coefficient. Sensitivity and specificity of the points that define each of the activity levels were established by ROC curves to determine the discriminative capacity of SLE-DAS.ConclusionIn this population of lupus patients from Argentina, the SLE-DAS allowed to discriminate between remission and disease activity, being a useful and practical tool.Disclosure of InterestsNone declared