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New quinoline derivatives containing biphenyl ring were synthesized and characterized by IR, 1H NMR and mass spectral studies. The synthesized compounds were screened for antimicrobial, anthelmintic activities as well as free radical scavenging property against the DPPH radical. The minimum inhibition concentration values showed promising inhibiting activity and are potent biological agents. The compounds showed minimum binding energy towards β-tubulin. The compounds 11a, 11c, 13c and 13d have good affinity towards the active pocket and may be considered as a good inhibitor of β-tubulin.

A series of novel [1,2,4]-triazolo piperidine (8), [1,2,4]-triazolo piperazine (9a-c), [1,2,4]-triazolo phenylether (10a-e), and [1,2,4]-triazolo aniline (11a-c) derivatives have been synthesized. The chemical structures of the newly synthesized compounds were characterized by IR,1H NMR,13C NMR, and LCMS. The newly synthesized compounds were screened for antimicrobial activity. Among all the compounds tested,11b(R4=4-MeO–) showed the highest activity againstStaphylococcus aureusandEscherichia coli, and9a(R1andR2=Cl) showed the highest activity againstPseudomonas aeruginosa.

Hepatitis C Virus (HCV) encodes its own RNA dependent RNA polymerase (NS5b) in order to replicate its genome. An efficient pharmacophore was identified, by executing structural analysis of a set of 49 indole-based inhibitors of the HCV NS5B polymerase. Identified pharmacophoric features, two hydrophobic regions, and 4 aromatic rings i.e. HHRRRR.649. Ligand based 3D-QSAR was performed, partial least square regression analysis was employed which gave a regression coefficient R 2 of 0.98 and Q 2 of 0.88, and Pearson-R of 0.96. Article Info

Synthesis of New Biphenyl-Substituted Quinoline Derivatives, Preliminary Screening and Docking Studies. -All new compounds exhibit good antimicrobial, antioxidant as well as anthelmintic activities. Especially compounds (IV), (VIIIb), and (IXb) show good docking scores with -tubulin protein. -(SHASHIKUMAR*, N. D.; KRISHNAMURTHY, G.; BHOJYANAIK, H. S.; LOKESH, M. R.; JITHENDRAKUMARA, K. S.; J. Chem. Sci. (Bangalore, India) 126 (2014) 1, 205-212, http://dx.