Chronotherapy refers to the use of circadian, ultradian, infradian & seasonal, or other rhythmic cycles in the application of therapy. There are a number of conditions that show a circadian pattern and advantages could be taken by timing and adjusting the administration of drugs according to the circadian rhythm of the disease. Chronotherapy can be divided into three categories: time-controlled systems, in which the drug release is primarily controlled by the delivery system; stimuli-induced PDDS, in which release is controlled by the stimuli, such as the pH or intestinal enzymes; or externally regulated systems, in which release is programmed by external stimuli such as magnetism, ultrasound, electrical effect, and irradiation. The symptoms of some diseases, such as asthma, arthritis, depression, ulcer, allergic rhinitis, sleep disturbances, etc., are influenced by circadian rhythms. The biological clock of the human body is based on solar and lunar adaptations. The circadian rhythm is the primary rhythm that the biological clock adheres to. The functioning of the brain, behavior, and cognition can all be significantly impacted by circadian rhythm disruption. The use of chronotherapeutics can help with this. The recent interest that has occurred in the field of chronotherapeutics is to match the circadian rhythms of the disease for the successful treatment of the disease.