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Biotransformation reduction of 2-(4-methoxybenzyl)-1-cyclohexanone was investigated. A method was elaborated for the preparation of some diastereoisomeric alcohols derived from the racemic title ketone and for the determination of the products obtained. The study resulted in the synthesis of cis-(1S,2S)-(+)-2-(4-methoxybenzyl)-1-cyclohexanol and trans-(1S,2R)-(+)-2-(4-methoxybenzyl)-1-cyclohexanol in optical purity of at least 91.6 ± 1.0% and 97.5 ± 1.0%, respectively.

The syntheses of various 2-(4-hydroxybenzyl)-1-cyclohexanone derivatives are described in connection with the development of the research of substances with juvenile hormone activity.

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