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The thermal neutron flux achieves its maximum value in the core of reactor but reduced at extreme ends of the reactor core, few thermal neutrons are produced in this area. Hence the flux distribution is strongest at the middle of the reactor's core 2008; Musa et al., 2011). However, the flux of a Reactor is a variable parameter that depends on the Reactor's moderator and coolant temperature. Epithermal neutron activation analysis (ENAA) method is a technique which is ideally suited for determination of key trace elements in geological, biological and environmental samples which cannot be acc traditional use of thermal neutrons (Ahmed et al., 2013). The ENAA tech one of the most highly developed experimental nuclear physics (2013). The method became popular because gamma ray detection and gamma spectrum determination which forms the essential measurement at every step in nuclear spectroscopic experiments was optimized in recent years (Ahmed et al., 2010). The advantages pertaining to the potential use of epithermal neutrons to overcome background interferences from thermall elements has been generalized in a by (Decorte et al. 1972). Over the years, determination the dynamic behaviour of ABSTRACT Nigerian Research Reactor-1 (NIRR Cadmium line due to high demand for epithermal neutrons irradiation by the clients and cadmium poison to regulate the reactivity of the reactor a range value 4.0mk to 3.7mk. Safety and flux stability. Simulations were carried out via Monte Carlo Transport Code MCNP5 for calculation were done. The results of all these research work revealed that the effect of cadmium-line on safety and flux stability is the reactivity of the reactor after 1 results obtained for excess core reactivity after (2.96 and 2.95) mk, and predicted power of 14.65 kW for the two experiment respectively. These show that the change in power of the reactor is very small. of the research will help sample handling capabilities of NIRR the MNSR.