Background: Ethiopia meets the target millennium development goal 4 on child survival three years ahead of time. However, there were high perinatal deaths in the country and the reduction was not impressive. Identifying determinants and implement evidence based interventions is crucial to reduce perinatal death. However, there were no clear evidences on determinants of perinatal mortality in Tercha General Hospital.Objective: To assess determinants of perinatal mortality in Tercha general hospital, Southern Ethiopia, January 1, 2014 and December 30, 2017.Method: An unmatched case control study using secondary data as a source of information was conducted in Tercha general hospital. Cases were stillbirths and early neonatal deaths. Controls were those newborns live till 7th days. Randomly selected 366 (183 cases and 183 controls) study subjects were constituted for this study. The data were collected from March 1-20/2018. Epi-Data version 3.1 and SPSS Version 23 were used for data entry and analysis, respectively. Descriptive statistics were used to describe the study population in relation to study variables. Logistic regressions were employed to identify determinants of perinatal death.Results: In multivariable logistic analysis, rural in residence of the mother [AOR=1.82; 95%CI:(1.04-3.19)], ANC booking [AOR=0.47; 95%CI:(0.27,0.83)], prolonged labour [AOR=2.75; 95%CI: (1.58-4.78)], low birth weight [AOR=1.78; 95%CI (1.06-2.97)], presence of obstetrics complication [AOR=2.15; 95%CI: (1.28-3.62)], using partograph [AOR=0.5; 95%CI: 0.25-0.9]. Using safe child birth checklist [AOR=0.52; 95%CI: 0.30-0.91], and coming with referral [(AOR=2.69; 95% CI: (1.51-4.8)] were significantly associated with perinatal mortality. Conclusion and Recommendation: Being rural in residence, coming with referral, low birth weight, prolonged labour and presence of obstetric complication were associated with elevated the risk of perinatal mortality, and antenatal care booking, using partograph and using safe childbirthchecklist were associated with reduced risk of perinatal mortality. We therefore, recommend strengthening maternal health and newborn care servicesby taking into account these factors to reduce perinatal death.

Arsenic is a potentially toxic agent for human health due to its widespread presence in the environment. Arsenic poisoning from drinking contaminated groundwater has become one of Bangladesh's most difficult healthcare problems. However, there is a lack of understanding of the detrimental impact of arsenic toxicity on children of arsenic-exposed parents. This study evaluates the effect of arsenic toxicity on body growth, blood parameters, and organ development of F1 mice. In this study, adult female mice were exposed to sodium arsenite from gestation day 12.5 until parturition, and then the postnatal growth, blood indices, and organ development were assessed. The result showed that from birth to weaning offspring of the sodium arsenite-treated group exhibited significant (p<0.002, p<0.0001, p<0.0001 consecutively) and weaning to sexual maturity of female offspring significantly (p<0.01, p<0.01, p<0.0001 respectively) slower increase in final body weight, total body weight gain, and rate of body weight gain than that of the offspring of the control group. Hematological tests revealed a significant reduction (p<0.03, p<0.02) in RBC and WBC count while significant elevation (p<0.02) in Platelet count, MCV, MCH, and MCHC in offspring of sodium arsenite exposed female mice than the offspring obtained from control female mice. RBS and Triglycerides levels were significantly higher (p<0.05, p<0.0008 respectively), while Alkaline phosphatase level was significantly lower (p<0.02) in the offspring of sodium arsenite-exposed female mice than in the offspring obtained from control female mice. In terms of organ-to-body weight ratio, the female F1 mice from the exposed group demonstrated a significantly lighter (p<0.01) kidney and heart as compared to that of the female F1 mice from the control group. Visual inspection of the organ morphology showed a slightly affected liver, lungs, and testes. Overall, the study suggests that inorganic arsenic exposure of the parent mice exerts harmful effects on the body growth, hematological and biochemical parameters, and organ morphology of the offspring.