The nervous system is involved in different vital functions that guarantee the survival of the individual. Covid-19 infection is a multisystemic and multi organic disease that disrupts homeostasis and endangers the infected individual's life. It leads to neurological manifestations of varying intensity. However, the nervous system as a target of CoV-2 virus infection must be clarified. In this review we examine the expression of ACE-2 receptor and the interaction of Co-2 virus with nerve cells, describing some findings in nerve cells of different organs. Additionally, a CoV-2 dissemination map is postulated, with emphasis on the nervous functions at the somatic and autonomic levels.