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PurposeTo prospectively investigate the change in central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness in eyes with Vogt‐Koyanagi‐Harada (VKH) disease in through 24 months follow‐up.MethodsTwelve eyes of 6 treatment‐naïve patients with acute VKH disease associated with optic disc swelling and serous retinal detachment and 30 eyes of 15 normal individuals were enrolled to investigate the changes of CMT and average RNFL thickness. Retinal thickness were measured at first visit and months 6, 12 and 24 via spectral domain optical coherence tomography (SD‐OCT).ResultsCMT was significantly lower in the eyes of VKH group at 12 (246.58 ± 21.80 μm vs. 258.60 μm ± 15.61, p < 0.05) and 24 months visit (226.67 ± 14.21 μm vs. 253.15 ± 15.84 μm, p < 0.05). RNFL thickness was significantly higher in the eyes of VKH group at initial visit, 6 and 12 months follow‐up visit, but no significant difference between VKH group and control group at 24 months follow‐up visit (95.83 ± 14.85 μm vs. 97.14 ± 12.97 μm, p > 0.05).ConclusionsThere were significant changes of CMT and RNFL thickness in the eyes with VKH disease during 24 months follow‐up period. Detecting or monitoring diseases including glaucoma and neuro‐ophthalmic diseases, which affect the retinal thickness in VKH patients, we recommend to consider the longitudinal change of the retinal thickness.