This chapter is intended to detail the properties of kaolinite-cellulose nano-composite, its preparation, characterization, and applications in various fields. The fields of applications cover the conventional areas of application like wastewater treatment, biomedical application, fuel cells as well as in advanced applications e.g. in the fields of packaging, flame retardant, printed electronics, etc. The brisk viewpoints on the challenges to fabricate nanostructured kaolinite, nanostructure cellulose, and their composite as well are discussed. The direction to tackle the said challenges and updates on the recently developed applications of kaolinite-cellulose nano-composites are discussed.