Introduction: Oral nifedipine & parenteral labetalol are most commonly recommended for treating hypertension disorders in pregnancy. The aim of the study was to compare the effectiveness & safety of both the drugs. Methods: Every pregnant woman with severe gestational hypertension >160/110 mmHg who came to our university hospital at Chidambaram were taken for the study. They received acute treatment by either nifedipine (10 mg tablet, orally, up to five doses) or intravenous labetalol injection (in an escalating dose regimen of 20, 40, 80, 80 and 80 mg) and a placebo tablet or 0.9% saline every 15 minutes until the target blood pressure of <150/100 mmHg was reached. Results: All the patients recruited in the study achieved blood pressure control. Most patients in both groups achieved the target blood pressure within 45 minutes or less (36.8 ± 15.3 minutes and 38.1 ± 12.2 minutes respectively in the labetalol and nifedipine) and received 3 or lesser number of doses (averaged 2.4 and 2.5 times in the labetalol and nifedipine). No crossover & not statistically significant adverse maternal or fetal outcomes were noted in both groups. Conclusions: Oral nifedipine and intravenous labetalol are similarly effective & safe in the acute control of severe hypertension in pregnancy.

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To study the D dimer levels as a predictor of severity of gestational hypertension. Methodology: A Prospective observational study was performed among the Antenatal women attending the Department of Obstetrics and Gynaecology in our institution. Blood samples were collected from 150 subjects under inclusion criteria and the D Dimer levels were estimated and the same was compared with the severity of the disease. Patients who were COVID positive and who had past history of thrombotic manifestations were excluded from the study. Results: In about 54% of the subjects evaluated, the D Dimer concentrations exceeded the normal range of more than 500 ng/dl. Higher concentrations of D Dimer levels were noted in patients with severe preeclampsia than in those with non-severe preeclampsia. Conclusion: Maternal concentrations of D Dimer were significantly elevated in patients with severe preeclampsia than in those with non-severe disease.