BackgroundThe present study assessed the efficacy of the residential, group-based, intensive holistic lifestyle intervention on glycaemic control. Materials and methodsA one-group pre and post-intervention study was conducted among 145 people with diabetes for a period of one year from February 2019 to January 2020. The study population underwent "Brahma Kumaris Raja Yoga lifestyle" intervention. Outcome variables were changes in HbA1c levels and anthropometric parameters (like weight, BMI, etc.). Paired t-test was used to compare normally distributed numeric variables. ResultsThe mean age was 52.39±5.79 years, with a male-female ratio close to 1:1. Mean HbA1c at baseline was 9.06±2.1%. The mean weight and BMI were 71.03±12.84 kg and 28.28±4.83kg/m 2 , respectively. Mean HbA1c value had shown a reduction of 1.60% (95%CI 1.17 to 1.90, p <0.001) at three months and 1.58% (95% CI 1.13-1.87, p<0.001) reduction at a six-month follow-up. Between the third and sixth months, there was no significant change in the HbA1c value. Mean weight reduced by 0.79 kg (95% CI 0.08-1.08, p=0.023) at sixmonth follow-up and mean BMI decreased by 0.31 units from baseline to three months (95% CI 0.05-0.56, p=0.017). A statistically significant reduction was observed in waist circumference at the third month (MD=1.61 95% CI =0.95 to 2.28, P<0.001) and sixth month (MD=1.53, 95% CI 0.82-2.25, p<0.001) follow-up. ConclusionThis residential, group-based, intensive holistic lifestyle intervention showed a significant decrease in HbA1c levels and anthropometric parameters at three-and six-months follow-up, thereby improving the overall health and wellbeing of people with diabetes.

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BACKGROUND: Laryngoscopy and endotracheal intubation is invariable in G.A. and is associated with increased sympathomimetic response. The present study compared the efficacy of esmolol and labetalol in low doses for attenuation of pressor response. MATERIALS & METHODS:This is a Prospective, randomized, placebo controlled study in which 75 ASA Grade I and II patients aged 18-45 yrs. undergoing elective surgical procedures, requiring G.A. and orotracheal intubation were taken up for the study. Patients were allocated to any of the three groups of (25 each). Group C (Control) received 10ml of 0.9% saline IV, Group E (Esmolol) were given 1mg/kg of drug diluted with 0.9% saline 10ml IV, Group L (Labetalol) were given 0.5mg/kg of the drug diluted with 0.9% saline 10ml IV. All the patients were subjected to the same anesthesia technique. HR, SBP, DBP were recorded prior to intubation, then 1 minute, 3 min, 5 min and upto 10min post intubation. RESULTS: Compared to placebo, esmolol and labetalol significantly attenuated HR, SBP, DBP during laryngoscopy and intubation. CONCLUSION: In lower doses, labetalol is a better agent than esmolol in attenuating the sympathomimetic response to laryngoscopy and intubation.

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