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Kyrle's disease with keratotic papules and nodules combined with a typical histologic pattern of epidermal penetrating hyperkeratosis is considered a perforating dermatosis. Consequently there are various clinical and histopathological differential diagnoses. Less than 80 case reports are published in the literature. So far the etiology of this dermatosis is unknown. Singular familiar appearance and more often associated metabolic disorders, e. g. diabetes and renal failure were seen. We report on 2 male patients with hyperkeratosis follicularis et parafollicularis in cutem penetrans and discuss the disease with respect to the literature. Kasuistik 240Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.