Summary:Blood cell transplantation (BCT) is now common practice in the autologous setting. We performed a pilot study of allogeneic BCT, collected after the priming of an HLA-identical sibling with a glycosylated rhu-G-CSF (lenograstim) (10 g/kg). genitors allows easy harvest with cytapheresis, and collection of a better quality graft than after traditional BM harvest.2 In the autologous setting, this effectively leads to faster neutropenic reconstitution but also to accelerated platelet reconstitution. This quicker hematopoietic recovery resulted in decreased transplant-related morbidity, shorter duration of hospitalization and reduced transfusion requirement.3,4 Associated with a reduction in procedural cost this motivated physicians to consider autologous transplantation for a larger number of patients. The shift from BM to blood cell (BC) transplantation occurred within a few years and coincided with a rapid increase in the number of autologous transplants world-wide. 5 The rapid development of autologous BC transplantation (BCT) provided the necessary experience and led to modification of the procedure for the allogeneic setting. In this situation, early interest arose for the same reasons as in the autologous situation: harvesting cells easily and without general anesthesia from normal donors, infusing more progenitors and so potentially decreasing morbidity and costs. The main expectation, in this setting, remains that the change in technology will induce a substantial decrease in transplant-related toxicity.

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Myelosuppression is the major dose-limiting toxicity of chemotherapy in small cell lung cancer (SCLC). The capacity of colony stimulating factors (CSFs) to stimulate granular neutrophil recovery may be of great value to prevent or cure febrile neutropenia and to increase dose-intensity. The aim of this review was to assess the current use of CSFs in SCLC on the basis of experimental and clinical data.Primary CSF administration has been shown to reduce the incidence of febrile neutropenia, hospital admission rate, and antibiotic use subsequent to cyclophosphamidedoxorubicin-high dose etoposide (CDE) chemotherapy, without improvement of survival or disease control. Primary CSF administration may be recommended when the expected incidence of febrile neutropenia is at least 40%. This benefit has not been established with less myelosuppressive regimens, such as cisplatin-etoposide (PE), which remains an alternative combination in SCLC when standard doses are used. A trial comparing high-dose CDE + CSF with PE would be of considerable interest.There is currently little clinical basis for the use of CSFs to increase chemotherapy dose-intensity, outside clinical trials. Peripheral blood progenitor cells mobilized with CSFs offer interesting prospects. Further studies, with later initiation, shorter duration or lower doses of CSFs, are warranted to improve the cost-effectiveness of CSFs.CSF therapy in addition to antibiotics is normally not justified in febrile neutropenia, except perhaps in selected patients with sepsis syndromes, hypotension or pneumonia.

Der chroni5che Blasenkatarrh entwickelt sich entweder aus einem acuten oder er entsteht von vorneherein unter den ihn charakterisirenden Erscheinungen als chronischer in Folge mangelhafter Entleerung der Blase oder unter der Einwirkung cines Fremdkdrpers. Der ursächlichen Momente werden sehr viele aufgezählt. In der Mehrzahl führen jedoch diejenigen Processe zum chronischen Blasenkatarrh, welche mit einer mehr weniger unvollständigen Entleerung der Harnblase verbunden sind. Das sind demnach die Vorengerungen der Harnröhrenlicbtung, welche durch Stricturen und Prostatahypertrophie geschaffen werden und dann die Paralyse der Blasenmusculatur, welche theils auf genuinrr Atrophie, theils auf Störungen der Innervation beruhen kann. Jener begegnet man bei alten Leuten, letztere ist bekannt-4 lichi ein regelmässiges Symptom ge*isser Erkrankungen der Centralorganei besonders traumatischer Zerstörungen des Rückenmarks.

IV. M. Schüller. Experimentelle und histologische Untersuehungen über die Entstehung und trachen der S croph.ul Ösen und tuberculösen Gelenkle ide n S. 148ff. Referent P. B. Dies hervorragende Werk unseres verehrten Mitarbeiters ist freilich schon in No. 10 von competenter Seite eingehend gewürdigt worden, es schien aber nichts desto weniger geboten, im Hinblick auf Koch's Untersuchungen dem betreffenden Kapitel in Sc h û lie r s Ausfiihrungen noch eine specielle Besprechung zu widmen. Der Verf. fiihrt aus, dass Tuberculose, Scrophulose und Lupus nur verschiedene Erscheinungsformen derselben Infectionskrankheit, der Tuberculose,