Interference is one of the burning issues in the field of Communication. The discovery of data, interpretation and gaining knowledge from the data is a crucial phase in everyone's day to day life. Wi-Fi and Bluetooth play a crucial segment for transferring data between two domains. Wi-Fi and Bluetooth use the same unlicensed Industrial, scientific and medical band. Its frequency range is 2.4GHz. Because of the band, interference may occur due to co-located devices.Since the utility and demand of Wi-Fi and Bluetooth devices has increased, co-located devices have also increased in number. In this paper, a new technique is proposed in which the modulation techniques to improve the performance of Wi-Fi and Bluetooth co-located systems are discussed. By using least square error based estimation, BER over the Wi-Fi and Bluetooth environment is decreased. SNR gives the bit error rate of Wi-Fi and Bluetooth for each modulation technique. In this paper, different modulation techniques are performed for calculating the efficiency in the presence of interference and absence of interference.

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