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Background It is postulated by some authors that neurological disturbances, thrombosis, ocular lesions and other severe clinical signs of Behcet’s disease (BD) are most common in males (m) than in females (f). Objectives To compare the frequency of main clinical features of BD in males and females from Dagestan ethnic cohort. Methods 85 patients with BD (ISBD criteria) were enrolled (m=63, mean age 31±9,8 years, f=22, mean age 29±8,6 years. M/F ratio was 2,8:1. Disease duration in m was 11,27±7,4 years, in f - 7,8±7,1 years. Results The main features of BD in m and f are summarized and compared in Table 1. Oral aphthosis occurred with the same frequency in m and f and was 98%. Uveitis, retinal vasculitis and skin lesions were more often in men than in women with BD. Moreover, severe symptoms of BD, such as vasculo-Behcet, or venous thrombosis developed more frequently in males. There was no difference in the frequency of central nervous system and gastro-intestinal damage between m and f with BD. Conclusions It is obvious that disease course is more serious in males than in females with BD from Dagestan ethnic cohort. Possibly there is an influence of HLA-B51 positivity. This antigen appeared to be positive in 75% of males and 47% of females. Disclosure of Interest None Declared

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