Our aim is studying the thermodynamics of cosmological models including initial and final de-Sitter eras. For this propose, bearing Cai-Kim temperature in mind, we investigate the thermodynamic properties of a dark energy candidate with variable energy density, and show that the state parameter of this dark energy candidate should obey the ωD = −1 constraint, whiles there is no interaction between the fluids filled the universe, and the universe is not in the de-Sitter eras. Additionally, based on thermal fluctuation theory, we study the possibility of inducing fluctuations to the entropy of the dark energy candidate due to a mutual interaction between the cosmos sectors. Therefore, we find a relation between the thermal fluctuations and the mutual interaction between the cosmos sectors, whiles the dark energy candidate has a varying energy density. We point to models in which a gravitationally induced particle production process leads to change the expansion eras, whiles the corresponding pressure is considered as the cause of current acceleration phase. We study its thermodynamics, and show that such processes may also leave thermal fluctuations into the system. We also find an expression between the thermal fluctuations and the particle production rate. Finally, we use Hayward-Kodama temperature to get a relation for the horizon entropy in models including the gravitationally induced particle production process. Our study shows that the first law of thermodynamics is available on the apparent horizon whiles, the gravitationally induced particle production process, as the dark energy candidate, may add an additional term to the Bekenstein limit of the horizon.