Hepatitis C virus (HCV) is a member of Flaviviridae family and one of the major causes of liver disease. There are about 175 million HCV infected patients worldwide that constitute 3% of world's population. The main route of HCV transmission is parental however 90% intravenous drug users are at highest risk. Standard interferon and ribavirin remained a gold standard of chronic HCV treatment having 38-43% sustained virological response rates. Currently the standard therapy for HCV is pegylated interferon (PEG-INF) with ribavirin. This therapy achieves 50% sustained virological response (SVR) for genotype 1 and 80% for genotype 2 & 3. As pegylated interferon is expensive, standard interferon is still the main therapy for HCV treatment in under developed countries. On the other hand, studies showed that pegylated IFN and RBV therapy has severe side effects like hematological complications. Herbal medicines (laccase, proanthocyandin, Rhodiola kirilowii) are also being in use as a natural and alternative way for treatment of HCV but there is not a single significant report documented yet. Best SVR indicators are genotype 3 and 2, < 0.2 million IU/mL pretreatment viral load, rapid virological response (RVR) rate and age <40 years. New therapeutic approaches are under study like interferon related systems, modified forms of ribavirin, internal ribosome entry site (HCV IRES) inhibitors, NS3 and NS5a inhibitors, novel immunomodulators and specifically targeted anti-viral therapy for hepatitis C compounds. More remedial therapies include caspase inhibitors, anti-fibrotic agents, antibody treatment and vaccines.
Lightning strokes are known to cause direct heating and ionization of the D region, some of which are detected via scattering of VLF transmitter signals and are known as Early VLF events. The disturbed ionosphere typically recovers in many tens of seconds. New experimental evidence is presented demonstrating that the scattering pattern and onset amplitude of Early VLF events are strongly related to both the magnitude and polarity of causative lightning peak current. Observations of Early VLF events at nine Stanford VLF receiver sites across the continental United States are combined with lightning geolocation data from the National Lightning Detection Network (NLDN). During January and March 2011, NLDN recorded 7769 intense lightning discharges with high peak currents (>100 kA) generating 1250 detected Early VLF events. We show that the size of the scattered field due to the ionospheric disturbance increases with the peak current intensity of the causative lightning discharge. The most intense peak currents of >+200 and <−250 kA disturb VLF transmitter signals as far as ∼400 km away from the lightning stroke. Early VLF event detection probability also increases rapidly with peak current intensity. On the other hand, the observed VLF amplitude change is not significantly dependent on the peak current intensity. Stroke polarity is also important, with positive strokes being ∼5 times more likely to generate Early VLF disturbances than negative strokes of the same intensity. Intense positive cloud‐to‐ground lightning discharges, especially when occurring over the sea, are also more likely to produce Early VLF events with long recovery (many minutes).
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