Background:The incidence of scalp neoplasms is continuously increasing as a consequence of the progressive aging of the population. The need to perform a correct excision of scalp neoplasms often requires the removal of the entire skin, galeal and periosteum lining. The consequent complete uncovering of the thecal bone does not allow any type of local grafting and, in the past, has always involved the need to carry out the recovering using local or free flaps. The preparation of the local flaps generally involves large detachments of the scalp, which can cause severe complications of the haemorrhagic type, especially in elderly patients with anticoagulant or antiplatelet treatments. The realization of free flaps, on the other hand, involves a greater anesthetic effort and the creation of a further sacrifice in the donor site. Methods:The introduction of Dermal Regeneration Templates made it possible to undertake repairing techniques for full-thickness lesions of the scalp with the simple aid of local anesthesia without the need to suspend antiplatelet treatments. The interventions based on the use of Dermal Regeneration Templates are not complex, however they require particular and simple measures which, if not applied, lead to not entirely satisfactory results. This work describes a method of using Dermal Regeneration Templates in the repair of full-thickness lesions of the scalp that follows a rigorous protocol as result of constant internal review.In particular, we identified three details leading to better results:• continuous Ford interlocking suture with "double pass" in the DRT;• tie-over compression fixed by sutures anchored approximately 5-8 mm externally to the margins of the main suture (8 points);• antibacterial ointment sealing. Conclusions:In our opinion, a correct protocol concerning surgical techniques and dressing management allows the shortening of Dermal Regeneration Templates placing times from 6 to 4 weeks; better results in terms of percentage of area with good flourishness, less fluid collection under the Dermal Regeneration Templates and consequently the formation of a more homogeneous and better quality neoderm.