As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a first phase, the vaccination process is studied as a new compartment in the model, and different ways of distributing the vaccines investigated: pediatric and random mass vaccines, with distinct levels of efficacy and durability. In a second step, the vaccination is seen as a control variable in the epidemiological process. In both cases, epidemic and endemic scenarios are included in order to analyze distinct outbreak realities.
This paper is devoted to the study of the initial value problem of nonlinear fractional differential equations involving a Caputo-type fractional derivative with respect to another function. Existence and uniqueness results for the problem are established by means of the some standard fixed point theorems. Next, we develop the Picard iteration method for solving numerically the problem and obtain results on the long-term behavior of solutions. Finally, we analyze a population growth model and a gross domestic product model with governing equations being fractional differential equations that we have introduced in this work.
This paper deals with fractional differential equations, with dependence on a Caputo fractional derivative of real order. The goal is to show, based on concrete examples and experimental data from several experiments, that fractional differential equations may model more efficiently certain problems than ordinary differential equations. A numerical optimization approach based on least squares approximation is used to determine the order of the fractional operator that better describes real data, as well as other related parameters.
Epidemiological models may give some basic guidelines for public health practitioners, allowing the analysis of issues that can influence the strategies to prevent and fight a disease. To be used in decision making, however, a mathematical model must be carefully parameterized and validated with epidemiological and entomological data. Here an SIR (S for susceptible, I for infectious, and R for recovered individuals) and ASI (A for the aquatic phase of the mosquito, S for susceptible, and I for infectious mosquitoes) epidemiological model describing a dengue disease is presented, as well as the associated basic reproduction number. A sensitivity analysis of the epidemiological model is performed in order to determine the relative importance of the model parameters to the disease transmission.
Dengue is one of the major international public health concerns. Although
progress is underway, developing a vaccine against the disease is challenging.
Thus, the main approach to fight the disease is vector control. A model for the
transmission of Dengue disease is presented. It consists of eight mutually
exclusive compartments representing the human and vector dynamics. It also
includes a control parameter (insecticide) in order to fight the mosquito. The
model presents three possible equilibria: two disease-free equilibria (DFE) and
another endemic equilibrium. It has been proved that a DFE is locally
asymptotically stable, whenever a certain epidemiological threshold, known as
the basic reproduction number, is less than one. We show that if we apply a
minimum level of insecticide, it is possible to maintain the basic reproduction
number below unity. A case study, using data of the outbreak that occurred in
2009 in Cape Verde, is presented.Comment: This is a preprint of a paper whose final and definitive form has
appeared in International Journal of Computer Mathematics (2011), DOI:
10.1080/00207160.2011.55454
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.