GCK-MODY is one of the most common MODY variants (40–60 %) in the European population. It is possible to use continuous glucose monitoring systems (CGMS) when diagnosing GCK-MODY which allows for an analysis of glucose variability (GV) using mathematical indices and a detailed assessment of the glycemic profile. The purpose of this abstract is to investigate the features of GV in young people with GCK-MODY. A daily study of glucose levels was performed using portable systems for CGMS in 20 patients (7 men and 13 women, median age at diagnosis of DM was 28.0 [18.0; 36.0] years) with a mutation in the glucokinase gene confirmed by molecular genetic testing. There was also performed an analysis of glycemic variability indices with the specialized GLINVA program. Most patients with GCK-MODY have target values when determining routine indicators of carbohydrate metabolism (fasting plasma glucose (FPG) and glycated hemoglobin), they determines the tactics of managing patients from this group of patients (rational nutrition or minimal doses of oral hypoglycemic drugs). However, after conducting CGMS and studying the GV indices it was determined that in some patients the indices were higher than the reference values with normal levels of glycated hemoglobin and FPG, and it is this group of patients that needs therapy correction. The results demonstrate a flat glycemic profile during the day which probably causes a lower incidence of diabetic complications and determines the tactics of GCK-MODY patient management.

Objective. Arterial hypertension (AH) and diabetes mellitus (DM) are frequent comorbid diseases, which are associated with a high level of disability and mortality. According to the literature hypertension occurs in 50–80% of patients with type 2 diabetes (DM2) (which constitute more than 90% of the population with type 2 diabetes), compared with 30% of patients with type 1 diabetes (DM1). Comparative studies on the frequency of AH in young patients with different types of DM in the Siberian region have not been conducted. The aim of the research work was to study the frequency of AH and associations of AH with clinical and laboratory parameters in various types of DM diagnosed before the age of 45 years.Design and methods. 174 patients with the onset of DM from 18 to 45 years old were included. They were under observation at the Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences: in 20 patients DM1 was verified (group 1), in 80 — DM2 (group 2), 20 had HNF1A-MODY (Maturity-Onset Diabetes of the Young) (group 3), 36 had GCK-MODY (group 4), 18 had LADA (“latent autoimmune diabetes in adults”) (Group 5). All patients was done a clinical examination, determination of indicators of carbohydrate metabolism and basic biochemical parameters.Results. All groups were comparable in terms of gender, age, and duration of DM. AH of 1–2 degrees in group 1 was detected in 5 patients (25,0%), in 2 — in 20 people (25,0%), in 3 — in 5 (25,0%), in 4 — in 4 (11,1%), in 5 — in 4 (22,2%), significant differences were not identified. In different types of DM the development of AH is associated with various clinical and laboratory parameters. In DM1, the development of AH has a correlation with the age of the patient, with the level of low-density lipoprotein cholesterol; in DM2 — with the duration of diabetes, the patient’s age, body mass index, glucose level, lipid spectrum and diabetic complications; with HNF1A-MODY— with diabetic complications; with GCK-MODY — with the duration of diabetes, the age of the patient, with the level of total cholesterol, with the development of nephropathy; with LADA — with indicators of carbohydrate metabolism and triglycerides.Conclusions. It is necessary to screen for the presence of AH for any type of DM in young people. It is necessary to take into account the clinical and laboratory parameters associated with the AH depending on the type of DM.

Introduction. Rare types of diabetes mellitus including MODY (Maturity-Onset Diabetes of the Young) are quite complicated to verification and differential diagnosis. That is often leads to diagnostic delays, medical errors in choosing treatment tactics. This kind of event could aggravate the course of the disease and must be prevented.Aim. Evaluation the characteristics of glucose variability (GV) in different types of diabetes mellitus (DM) in young people using continuous glucose monitoring (CGM) systems is necessary to understand the diagnostic value of the method.Materials and methods. We studied 72 patients with clinical signs of MODY who underwent a molecular genetics study to verify the type of DM. According to the results of the study, patients were divided into 3 groups: with genetically confirmed MODY2 (n = 31), MODY3 (n = 16); comparison group consists of the patients with type 2 diabetes (n = 25). All patients at the second stage underwent CGM for 14 days. At the third stage, the obtained patterns of glycemia were presented in the form of GV indices using the GLINVA program, and an in-depth analysis of glucose variability was performed.Results. Some features in the characteristics of the glycemic profile in young people with monogenic forms of DM were noticed. It was determined that in MODY2 the level of fasting plasma glucose (FPG) (p = 0.004) and HbA1c (p = 0.010) was significantly lower than in MODY3, and low GV was determined during the day, which probably causes a lower incidence of diabetic complications than other types of  diabetes. In individuals with MODY3, higher FPG and HbA1c values were found, in  contrast to MODY2 and type 2 diabetes. MODY3 profile is characterized with significantly higher GV and longer time spent above the target ranges (compared to type 2 diabetes).Conclusions. The approach to evaluate the glycemic profile used in the study is modern and affordable. It could become a tool for determining criteria for diagnosing the type of diabetes in patients with clinical manifestations of MODY.