The pharmacological correction of the mineral composition of animal nutrition has been substantiated. The analysis of the results of studies of fodder by veterinary laboratories of the Novosibirsk region for the period 2018–2019 was carried out. It has been established that in the production of animal fodder such crops as wheat, barley, oats, millet, corn, peas, and soybeans are used. Cereals make up about 85% of the compound fodder, legumes – 45%. It is noted that the mass fraction of moisture and dry matter in all types of animal fodder is within the permissible ranges of the norm. In winter cows are fed with hay, silage and mixed fodder. So protein deficiency (10.69 ± 0.35%) occurs for milk yield above 10 kg per day. The largest amount of crude protein is contained in the meal (36.48 ± 1.31%), the least is in silage (3.08 ± 0.12%). Crude fat is mainly contained in the millcake (9.68 ± 0.83%), and its minimum content is characterized by feed concentrates (0.49 ± 0.39%). Rough forage – hay and straw are rich in fiber (27.04 ± 0.58 and 36.87 ± 1.29%, respectively). A low level of calcium was found in fodder such as silage and grain used for feed purposes – 2.07 ± 0.11 and 2.22 ± 0.21 g / kg, respectively. Potassium deficiency was detected in compound animal fodder (2.75–3.03 g / kg), which requires correction of the diet. A low phosphorus content is noted in roughage, silage, grain (0.07–0.27%). The forage obtained during the ensiling process is provided with zinc at 8.02 ± 1.51 mg / kg, which is a low figure. The iron content in the compound feed is at an average level of supply – 40–50 mg / kg. Evaluation of the mineral composition of different types of feed showed the highest frequency of deviations in the amount of zinc – 42.5%. There are also significant fluctuations in the content of phosphorus and calcium in feed – 26.25 and 23.75%, respectively.

The authors conducted the study based on the experimental quail farm SRDIAH SFSCA RAS (Siberian Research and Design Institute of Animal Husbandry Siberian Federal Scientific Center for Agrobiotechnology of the Russian Academy of Sciences) and at the Department of Obstetrics, Anatomy, and Histology of the Novosibirsk State Agrarian University. The study aims to change the content of micro- and macroelements in the blood of quails of the Japanese meat breed when using the Biocalcium feed additive. The productivity of animals depends on their health and is determined by their metabolism level. Birds, unlike other animals, have an intensive mineral metabolism.Calcium and phosphorus are two biologically active components with many functions that determine ana- and catabolic processes. When oviposition begins, the calcium and phosphorus concentration in chickens’ blood serum increases. But the rate of exchange of these macronutrients is determined by the activity of oviposition, so control over the content of these substances is relevant. Indicator enzymes that perform certain intracellular functions and enter the blood from the tissues are informative indicators for assessing metabolism. Using the activity index of alkaline phosphatase is reasonable to evaluate calcium-phosphorus metabolism. Using the feed additive Biocalcium in the blood of quail of the experimental group increased the calcium concentration by 0.2%. If we talk about zinc, iron, and magnesium indicators, they increased by 0.1-0.3%. It was also found that the introduction of fiber in feed rations had a definite effect on protein metabolism. During the experiment, it was found that the feed additive based on Siberian silver fir substrate Biocalcium has no apparent negative impact on the body of the quail. The additive is effective at a late stage of rearing. The authors note an improvement in metabolism, the mineral composition of the blood is normalized; hematopoiesis is stimulated without changing the stability of hematopoiesis and the constancy of the blood composition due to the introduction of this feed additive into the diet of birds.

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The article presents the therapeutic efficacy of Biozinc in the treatment of cattle with serous mastitis. The authors revealed a decrease in the number of somatic cells in milk in the experimental group of cows to 170 thousand, which corresponds to the milk from a healthy animal. Cows in the experimental group showed a positive trend in milk quality. Five cows had watery milk. Positive changes in milk quality were evident 12 hours after the first injection in the form of a reduction in flake secretion from the affected quarters. Milk was watery in all cows of the experimental group by the third day, without flakes and white color. The authors note a positive trend during disease treatment by the end of the first day of treatment in both test groups. Complete recovery was noted in ten animals, which was 100%, in the experimental group, which were treated with Biozinc. Complete recovery occurred after 3.00±0.15 days. The therapeutic efficacy was 100%. In the control group, seven cows (70%) recovered. A hematological examination revealed a 15.52 g/l (18.1 %) increase in hemoglobin level in the experimental group of animals and a 0.88 x 1012/l (P<0.05) increase in erythrocyte count. Through serum biochemical studies, the authors found that cows with serous mastitis showed changes in such parameters as protein, bilirubin, alanine aminotransferase (ALAT), and aspartate aminotransferase (ASAT). Cows in the experimental group showed a 21.5% (P<0.01) decrease in protein content after treatment. The values of ASAT in the control group decreased by 35.2%, and in the experimental group - by 42.6%. The values of ALAT also tended to decrease by 38.7% in the control group and by 48.6% in the experimental group (P<0.001).

The paper shows the impact of ultra-low concentrations of medical specimens on neutrophil opsonocytophagic reaction (ORR) parameters, such as phagocytic activity of neutrophils (PA), phagocytic number (PN), phagocytic index (PI), in vitro. The researchers observed the highest phagocytic activity in the control group 3 (placebo-control) in Creosotum C30 and, Ovarinine (P<0.01). When exploring the qualitative parameters of neutrophil opsonophagocytic reaction – phagocytic number – the authors observed the highest index in Ovarinine (26.79±5.13 m.t.), Secale cornutum C6 (16.57±0.46 m.t.) and Thuja D3 (15.58±1.30 m.t.). When estimating the phagocytic index in opsonophagocytic reaction, the inhibitory effect of saline solution (1.64±0.07 m.t.) was observed in relation to the placebo-control group No. 3 (2.42±0.21 m.t.) on 32.23%. The regularities revealed show that the lowest indexes of cellular immunity (FA, FF, FI) are established in Platinum C6; FF and FI - in Lilium tigrinum C12. The highest parameters of opsonocytophagic reaction were observed in the complex specimen Ovarinine, which includes Apis mellifelica C12, Pulsatilla pratensis C30, Sulfur C200, Sepia C6, Creazotum C30, Lachesis C12. Ovarinine is characterized by 9.65% increase in phagocytic activity, 997.95% in phagocytic number and 1106.76% in phagocytic index in comparison with the control group 1 with lactose.