A series of new 3-aryl-5-nitromethyl-1,2,4-oxadiazoles and their alkyl substituted derivatives has been synthesized and tested on cats. It is established that the synthesized compounds exhibit a pronounced hypertensive effect dependent on the nature of substituents in the benzene ring. * Deviations from the initial level reliable for p < 0.05. ** Relative to the initial average AP level.

A series of O-alkylamino derivatives of N-arylcarbamates have been synthesized via the reactions of methyl-N-( p-hydroxyphenyl)carbamate alkylation with 1,2-dibromoethane, 1,4-dibromobutane, and (chloromethyl)oxirane in acetone in the presence of K 2 CO 3 , followed by aminolysis of the intermediate compounds.The products were tested for the acute toxicity in mice and for the hyper-and hypotensive activity in cats. 3540091-150X/05/3907-0354

Phenol ethers Q 0270Hyper-and Hypotensive Activity of o-Alkylamino Derivatives of N-Arylcarbamates. -Among the title N-arylcarbamate derivatives, compounds (V) possess hypotensive activity while derivatives (VIII) show hypertensive properties. -(VELIKORODOV, A. V.; TYURENKOV, I. N.; TIMCHENKO, M. V.; PERFILOVA, V. N.; Khim.-Farm. Zh. 39 (2005) 7, 17-19; Astrakhan State Pedagog. Univ., Astrakhan 414050, Russia; Russ., Abstr. Eng.) -Mischke 49-081