This article overviews modern literature data on vulvar dystrophies. The increase in the number of patients with dystrophic diseases of the vulva, a pronounced tendency towards rejuvenation, the complexity of diagnosis, frequent recurrence of the disease and low effectiveness of therapy make this issue extremely urgent. Until now, morphologists have not developed a single classification, and among clinicians, a specific etiopathogenetic concept of development of vulvar dystrophies has not been determined. There are many theories of the disease development. The process starts asymptomatically and is not diagnosed in a timely manner, and due to the localization in the intimate area, it is characterized by low circulation and an increase in the number of neglected cases. Only a comprehensive, timely started treatment with the right choice of drugs and methods of activating reparative processes will prevent development of the disease and reduce the duration of the main symptoms and the likelihood of relapses, exacerbations, and complications.

This article presents a clinical case of a patient with colorectal cancer (CRC), who was diagnosed at the stage of a metastatic generalized process, due to a long asymptomatic course, non-specific symptoms and the difficulty of primary diagnosis. The features of management, as well as the possibilities of treating a patient with metastatic colorectal cancer (mCRC) at the present stage, are considered. This clinical observation demonstrates the relevance of the search for new diagnostic methods, treatment regimens and principles for the prevention of CRC.