24 weeks of study treatment. Improvement of median proteiuria reduction from base line was 64.2% at 12 weeks and 88% at 24 weeks. Serum vitamin D levels were inversely associated with the urinary protein creatinine UP/C ratio (p<0.001) and urinary vit D binding protein DBP/C (p<0.001). Conclusions Our findings show that new strategy of adding vitamin D therapy as new treatment for 24 weeks to maintain optimal serum 25(OH) D levels and diminish proteinuria in lupus nephritis patients. We need longer duration and more studies to confirm our results from different countries.