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Objective: The antinuclear antibodies (ANA) that present in the human serum have a link with various autoimmune diseases. Human Epithelial type-2 (HEp-2) cells acts as a substance in the Indirect Immuno fluorescence (IIF) test for diagnosing these autoimmune diseases. In recent times, the computer-aided diagnosis of autoimmune diseases by the HEp-2 cell classification has drawn more interest. Though, they often pose limitations like large intra-class and small inter-class variations. Hence, various efforts have been performed to automate the procedure of HEp-2 cell classification. To overcome these problems, this research work intends to propose a new HEp-2 classification process. Materials and Methods: This is regulated by integrating two processes, namely, segmentation and classification. Initially, the segmentation of the HEp-2 cells is carried out by deploying the morphological operations. In this paper, two morphology operations are deployed called opening and closing. Further, the classification process is exploited by proposing a modified Convolutional Neural Network (CNN). The main objective is to classify the HEp-2 cells effectively (Centromere, Golgi, Homogeneous, Nucleolar, NuMem, and Speckled) and is made by exploiting the optimization concept. This is implanted by developing a new algorithm called Distance Sorting Lion Algorithm (DSLA), which selects the optimal convolutional layer in CNN. Results: Through the performance analysis, the performance of the proposed model for test case 1 at learning percentage 60 is 3.84%, 1.79%, 6.22%, 1.69%, and 5.53% better than PSO, FF, GWO, WOA, and LA, respectively. At 80, the performance of the proposed model is 5.77%, 6.46%, 3.95%, 3.24%, and 5.55% better from PSO, FF, GWO, WOA, and LA, respectively. Hence, the performance of the proposed work is proved over other models under different measures. Conclusion: Finally, the performance is evaluated by comparing it with the other conventional algorithms in terms of accuracy, sensitivity, specificity, precision, FPR, FNR, NPV, MCC, F1-Score and FDR, and proves the efficacy of the proposed model.

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Cloud system is a set of resources meant to provide cloud customers with on-demand services. Accessibility to cloud environment is provided through internet services, making data stored on cloud more accessible to attackers internally and externally. Several intrusion detection systems and authentication methods have been developed in previous studies to identify the intruders, however they are generally unsuccessful with certain drawbacks. Numerous existing researchers have focused on machine learning techniques for identifying intrusions. This article intends to introduce a new intrusion detection model in the cloud and it involves three processes like preprocessing, feature extraction and detection. Initially, preprocessing takes place and the preprocessed data are subjected to feature extraction process. The flow-based features, statistical, and higher-order statistical features with improved holoentropy features, and the technical indicators are extracted. After extracting the features, they are subjected to a detection process, where the optimized radial bias function neural network (RBF-NN) is exploited. For precise detection, the weight of RBF-NN is tuned optimally by (harmonic mean based poor and rich optimization) HMPRO Algorithm. The main aim of the proposed model is to detect attacks in the cloud.Finally, the performance of the presented scheme is computed over the existing approaches using the CICDDoS2019 and UNSW-NB_15 dataset in terms of different metrics.